Endocrine Abstracts

Background: Oncocytomas are predominantly benign tumors that are well described in the kidney, thyroid and salivary glands. They have also been reported in more rare sites including the pituitary and parathyroid glands, respiratory tract and choroid plexus. The occurrence of these tumors in the adrenal gland, however, represents an extremely exceptional finding.Case presentation: We report the case of a 34 year-old male patient who presented with a right...

Background: Swyer syndrome is a type of pure gonadal dysgenesis 46 XY caryotype in phenotypically female patients. A rare case of Swyer syndrome complicated by dysgerminoma and Retiform Sertoli-Leydig cell’s tumor is reported.Case presentation: A 20-year-old phenotypically female patient presented to our department with primary amenorrhea. She was 1.68 m and weighed 82 kg (BMI 28). She presented with minimal breast development, sparse axillary and p...

Although the prognosis of thyroid cancer is in general quite favorable when standard management paradigms are applied, some patients do much less well. Radioactive iodine refractory, recurrent or metastatic disease is prognostically more worrisome. Sorafenib, a multitargeted small molecule kinase inhibitor, including the VEGF receptor and BRAF kinase, has been evaluated in patients with thyroid cancer. The aim of the study was to present a case of metastatic thyroid cancer and...

KLF11 is a pancreas enriched member of the Sp1/KLF transcription factor family which plays an important role in mammalian gene regulation. Previously we demonstrated that human (h)KLF11) inhibits human insulin promoter (hInsP) activity in rodent beta-cell lines via an unknown mechanism. Here we present results from ongoing experiments in which we test the hypothesis that KLF11 interferes with the major hInsP transactivator PDX1. We performed transient cotransfections of INS-1E...

Site-discordance in bone mineral density (BMD) assessment is common and affects patient categorization. Greater number of osteoporotic sites correlates with lower T score at each index site. The effect of BMD measurement at the contralateral femur on osteoporosis diagnosis has been previously evaluated.The aim of the study was to investigate the effect of BMD measurement at the contralateral femur on osteoporosis diagnosis.M...

Rathke cleft cysts (RCCs) are non-neoplastic sellar lesions derived from remnants of Rathke’s pouch, and mostly asymptomatic. Symptomatic RCCs occur usually in middle-age, are >1 cm, and cause pituitary hypofunction, diabetes insipidus, hyperprolactinemia or visual impairment. In children, RCCs are rare and usually asymptomatic. However, symptomatic cases may present with growth retardation and diabetes insipidus. We report two children with symptomatic RCC manifestin...

Background and aims: It is well recognized that insulin resistance and type 2 diabetes (T2DM) are associated with an increased risk for cardiovascular disease especially in women, while the role of sex steroids is still controversial. Women with polycystic ovary syndrome (PCOS) represent a unique biological model for the study of the impact of all these factors on cardiovascular system. We aimed to evaluate the degree of low-grade inflammation and atherosclerosis in premenopau...

Within the exocrine pancreas, p8 expression is induced by pancreatitis and protects exocrine tissue from inflammatory damage via inhibition of NFκB. In previous work, we investigated the role of p8 within the endocrine pancreas and characterised p8 as a glucose-dependent mediator of beta cell proliferation. Here we investigate the hypothesis that p8 protects beta cells from cell damage by the diabetogenic drug STZ. We investigated native and transiently transfected INS-1E...

Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disorder. The metabolic aspect of disorder is characterized by obesity-related risk factors for cardiovascular disease. The aim of this study was to determine in women with PCOS, indices of lipid metabolism and their oxidation, and to assess possible relation to insulin resistance. We investigated 75 women with PCOS (age: 23.1±5.1 years, body mass index (BMI): 24.9±4.7 kg/m2) and 56 age an...

Estrogens play an important role in male physiology. We investigated the possible association of four single nucleotide polymorphisms in estrogen receptor α (ER1) and Estrogen Receptor β (ER2) genes with circulating levels of sex steroids and Sex Hormone Binding Globulin (SHBG) in men.SHBG, total and calculated free testosterone (TT and cal FT), estradiol (E2) and free estradiol (FE2) were determined in a population based cohort of 170 apparent...